Endocrine Abstracts

Background: Sepsis is a life-threatening inflammatory condition and a leading cause of death in hospitals. It arises when a microbial infection triggers prolonged and uncontrolled systemic inflammation resulting in progressing organ dysfunction. Recent experimental data suggest a possible involvement of ferroptosis – an iron-dependent form of regulated necrosis – in sepsis-mediated damage of many vital organs. However, its role in adrenal gland dysfunction and/or dam...

Sepsis and septic shock remain a major health concern worldwide, and an intact adrenal cortex glucocorticoid (GC) stress response, is critical for organism to survive. Recently, we and others have shown that adrenal gland expresses members of toll-like receptors (TLRs) family which are known to sense pathogens and induce inflammatory response. Data performed on TLRs deficient mice clearly demonstrate a critical involvement of these receptors in immune-neuroendocrine bidirectio...

Evidence indicates that the adrenals are sexually dimorphic and asymmetric. These differences may have implications for the prevalence and progression of adrenal diseases, which also show asymmetry and sexual dimorphism. The present study aims to characterize the morphological and metabolic differences associated with adrenal sex and asymmetry in mice and humans. Adrenals were compared bilaterally in male and female C57B/6NRj mice with regard to morphological and hormonal char...